Endocrine Abstracts

It was previously shown that patients with primary hyperparathyroidism (PHPT) are insulin resistant.Aim: The aim of our study was to evaluate the effect of surgical treatment on glucose tolerance, insulin secretion and sensitivity (SI) in patients with PHPT.Material and methods: In 26 patients with PHPT (age: 57.15±9.54 years, BMI 26.00±4.55 kg/m2, PTH 276.61±64.83 ng/l, Calcium 2.95±0.19 mmol/l)) AIR...

Objective: It was previously shown that primary hyperparathyroidism (PHPT) might induce impaired renal function and chronic renal failure. The aim of our study was to evaluate the effect of surgical treatment on parameters of calcium and phosphate renal metabolism and renal function in patients with PHPT.Material and methods: In 26 patients with PHPT (age: 57.15±9.54 years, BMI 26.00±4.55 kg/m2, PTH 276.61±64.83 ng/l, Calcium 2....

Objective: It was previously shown that patients with primary hyperparathyroidism (PHPT) have atherogenic dyslipidaemia. The aim of our study was to evaluate the effect of surgical treatment on lipid levels in patients with PHPT.Material and methods: In 26 patients with PHPT (age: 57.15±9.54 years, BMI 26.00±4.55 kg/m2, PTH 276.61±64.83 ng/l, Calcium 2.95±0.19 mmol/l) Total cholesterol (TC), HDL-C, LDL-C, triglyceride (TG),...

Introduction and aims: Recent epidemiological studies have suggested serum gamma glutamyltransferase (GGT) within its normal range might be an early marker of oxidative stress. Oxidative stress appears to be a key component of many reactions associated with chronic inflammation. Obesity is associated with elevated levels of biomarkers of inflammation and endothelial dysfunction. Oxidative stress and inflammation are also known to play critical roles in the pathogenesis of vasc...

Polycystic ovary syndrome (PCOS) is associated with adiposity and metabolic changes predisposing to insulin resistance. Because the recently discovered GH secretagogue, ghrelin is intimately involved in the control of appetite and weight regulation, we investigate ghrelin levels in non-obese and obese PCOS patients. Ten obese (BMI=32.50±1.57 kg/m2) and ten non-obese (BMI=20.45±0.51 kg/m2) patients with PCOS and their respective controls were eva...

It was previously shown that patients with primary hyperparathyroidism (PHPT) are insulin resistant. The aim of our study was to evaluate the effect of surgical treatment on insulin sensitivity and lipid levels in patients with PHPT. In 21 patients with PHPT (age: 56.24±8.69 years, BMI 25.2±3.81 kg/m2) lipid levels (TC, HDL, LDL, TG, Lp(a)) and insulin sensitivity were determinated before and 4 months after surgical treatment. Insulin sensitivity was evalu...

Patients with primary hyperparathyroidism (PHPT) are insulin resistant. The effect of PHPT on lipid levels and low-grade inflammation leves is unknown. The aim of our study was to estimate the cardiovascular risk profile in patients with PHPT. Methods: In patients with PHPT (N=19; age: 58.15±8.38 years; PTH 180.83±104.15 ng/l, calcium 2.97±0.19 mmol/l) insulin sensitivity (measured using euglycemic hyperinsulinemic clamp - M value), lipids (total choleste...

It was reported that patients with primary hyperparathyroidism (PHPT) are insulin resistant, and that surgical treatment may improve insulin sensitivity in this group of patients. The aim of our study was to evaluate the effect of surgical treatment on insulin sensitivity in patients with PHPT. Methods: In patients with PHPT (N=19; age: 58.15±8.38 years) insulin sensitivity was estimated using euglycemic hyperinsulinemic clamp (M value) before and 3 months after su...

It was shown that obesity and insulin resistance may influence ghrelin levels. Contraversial results were observed considering ghrelin levels in women with polycystic ovary syndrome (PCOS). The aim of our study was to investigate the basal ghrelin levels in obese patients with PCOS and to evaluate possible correlations between ghrelin levels, insulin resistance and, androgen levels. In 10 obese PCOS patients (BMI 32.50±1.57 kg/m2, age: 21.4±0.85 years) and...

It has been shown that low values of insulin sensitivity have been related to metabolic diseases. Exercise prescription is crucial to prevent low insulin sensitivity in general population, and athletes are good physiological model. If this assumption is correct, examine insulin sensitivity in elite athletes should reflect the positive effect of exercise on insulin sensitivity. The aim of this study was to investigate the effects of regular exercise on insulin sensitivity estim...